By B. Karmok. University of Medicine and Dentistry of New Jersey.

Whether the organism had gained access through the oral cavity buy imitrex 50mg cheap muscle relaxant generic names, injury to the oral cavity by wood splinters order imitrex online now muscle relaxant chlorzoxazone, or skin puncture from wood slivers on the sideboards could not be ascertained buy imitrex 25mg visa quetiapine spasms. Lumpy jaw usually is a sporadic infection but, as in the aforementioned herd, can be an epidemic or endemic herd problem. External swelling is merely the tip of the iceberg as established by skull radiographs that conrm severe osteomyelitis with multifocal radiolucencies caused by rarefaction of bone. Because of distortion, malocclusion, or loss of teeth, eating becomes more difcult for severely affected cows. Salivation, reduced appetite, hesitant at- tempts to chew, and dropping food from the mouth may be observed. Draining tracts discharge copious quantities of serous or mucopurulent pus that should be considered infectious to other cows. Diagnosis Absolute diagnosis requires a tissue core biopsy or uid aspirate to identify the causative organism. Discussion of treatment also must allow for the tre- mendous variation in severity of osteomyelitis caused by A. Recently we have also been injecting antibiotic-coated (penicillin or eryth- romycin) beads into the lesion. Long-term antibiotic therapy has resulted in a surprising cure in a few ad- vanced cases. Surgery has been suggested and still is used by some as treatment for lumpy jaw of the maxillae. Surgical debulking or removal of large pyogranulomas project- ing from the skin of advanced cases may reduce the size of the lesion. In addition, the affected bone may be further compromised or fractured if overzealous debridement and curettage are performed. Loose teeth may require extraction, and stulous tracts may be ushed with iodine solution as ancillary aids. Ironically when this same un- Each of these major types may be further subdivided into treated cow eventually becomes ill as the lesion enlarges, subtypes. Therefore other treatments will need to usually occurs during the summer and fall, but one large be considered. In one comparative study, erythromycin epidemic developed during the late fall and early winter was active against A. Therefore cases to occur in the summer and fall is suggestive of an erythromycin may be a good choice. When epidemics occur, morbidity fed at 30 g/450 kg body weight once daily until iodism is high especially in dense populations of animals occurs. Fever may Bluetongue precede the more obvious signs because viremia is short-lived. Obvious problems with whereas sheep suffer a more apparent clinical disease mastitis occur when teat lesions are widespread. These acute signs in sheep progress to crust- naled by a few animals with obvious lesions, physical ing, erosions, and ulcers of the mucous membranes. In examination of other animals on the premises fre- addition, affected sheep are lame, resulting from both quently will reveal small erosions or ulcers resulting coronitis and myositis. Many of these signs cannot be distin- and other ocular anomalies or skeletal malformations. Oral lesions cause infected addition, there are at least nine serotypes of epizootic cows to eat less, thereby affecting production. Lame- hemorrhagic disease viruses a similar orbivirus that ness, if present, further deters appetite and access to primarily affects whitetail deer but can affect cattle caus- feed. Infection in cattle, goats, and possibly other wild ruminants can remain subclinical, but infected Treatment and Control hosts can act as reservoirs of disease. Sheep are the Common sense measures such as milking cows with major species to show clinical signs of disease. Multiple serotypes require specic testing rather in the milking parlor, reducing animal density, attempt- than group antigen testing for best detection. Softened feeds may be more fections in cattle thereby not arousing clinical sus- easily ingested by affected animals. Salivation is com- neutralization antibody tests primarily detected group mon, and swelling of lips may occur. Affected cattle should be kept out of sunlight if sistent infection of immunotolerant fetuses, and con- possible. If sheep reside on the premises, clinical signs may ern states, Great Plains, and West. Failure of laypeople to lubricate im- plements, judge appropriate depth of the oral cavity, or hold the animal s head and neck straight when adminis- tering oral medication are the most common errors. Small punctures may have few acute conse- quences but eventually result in cellulitis or pharyngeal abscesses. Local effects include pain, reluctance or inability to swallow, salivation, and cellulitis. Therefore early clinical Diagnosis signs of pharyngeal injury may be thought to represent Frequently the clinical signs, coupled with a manual failure of response or worsening of the primary condi- examination of the oral cavity to palpate the pharyngeal tion. Pharyngeal trauma is common in dairy cattle and laceration, are sufcient for diagnosis. Severe lacerations also may damage the soft palate or Clinical Signs proximal esophagus. Administered boluses or magnets The chief complaint in cattle with pharyngeal trauma is may still be embedded in the retropharyngeal tissues in anorexia and a suspected abdominal disorder that has some cases. An oral speculum and focal light examina- not responded to medication (including orally admin- tion also may allow a view of pharyngeal injuries. Direct tissue trauma is quickly Endoscopy and radiology are very helpful ancillary complicated by cellulitis or phlegmon of the retropha- aids, especially when a manual examination of the oral ryngeal tissue. Dysphagia may be present in severe cases and may lead to dehydration because of inability to drink. Other gastrointestinal signs caused by varying amounts of direct or indirect damage to vagal nerve branches may occur; these include bloat, rumen stasis, or signs of vagus indigestion. Subcutaneous emphy- Three representative Jersey cows from a herd with an sema is present in some patients as air is sucked into epidemic of pharyngeal trauma associated with mass the retropharyngeal area and dissects subcutaneously. Radiographs are Nursing procedures and ensuring access to fresh diagnostic of pharyngeal trauma in most cases because clean water and soft feeds such as silage or gruels of air densities and radiolucent retropharyngeal tissues are soaked alfalfa pellets are helpful. Antibiotic therapy should be continued 7 to Treatment 14 days or longer depending on response to treatment Broad-spectrum antibiotics, analgesics, and supportive and healing of the pharyngeal wound. Stomach tubes, specu- a good initial choice because it seldom is able to control lums, esophageal feeder tubes, and balling guns should the expected mixed infection. Judicious use of analge- be inspected after each use to identify any sharp edges sics such as unixin meglumine (0. Resolution of fever Etiology Papillomas and bropapillomas are observed sporadi- cally in the oral cavity, esophagus, and forestomach of dairy cattle. Jarrett and co-workers have also found a high incid- ence of papillomas and carcinomas of the upper alimen- tary tract and forestomach in cattle ingesting bracken fern in Scotland. Occasional warts at the cardia parent ventral to the cervical vertebrae, and the bolus or distal esophagus act as a ball valve to interfere with can be seen embedded between the air density dorsally eructation and cause chronic or recurrent bloat, leading and the trachea.

Even more striking is the finding that the numbers of activated buy genuine imitrex on line spasms bladder, S100`-immunoreactive astro- cytes in cerebral cortical tissue sections in Alzheimer s disease correlate with the extent of dystrophic neurite formation and the extent of neuritic expression of the `-amyloid precursor protein in Alzheimer s disease generic imitrex 25mg otc muscle relaxer z. These results collectively indicate that amyloid deposits in Alzheimer s disease are foci of immunological activity buy imitrex 25 mg with visa muscle relaxant for tmj, in contrast to the relative inertness of those diffuse amyloid deposits found in the nondemented elderly, and that this immunological activity correlates closely with neuronal injury and loss. This cascade includes several potentially neurotoxic steps, including raised intraneuronal free-calcium concentrations, overstimulation of neuritic outgrowth, and increased tissue levels of nitric oxide. Feedback mechanisms, with further activation of microglia and promotion of interleukin-1 overexpression, both sustain the immunological process and promote continuing neuronal injury. Known predisposing conditions for Alzheimer s disease, in addition to aging, include Down s syndrome and head injury. Patients with chronic, intractable epilepsy show accelerated appearance of Alzheimer-type "senile" changes. Normal aging is characterized by progressive increases in the numbers of activated astrocytes overexpressing S100` in the brain (56), and experimen- tal animals with accelerated senescence also show acceleration of this astrocytic S100` overexpression (57). Down s syndrome is a condition wherein the entire array of Alzheimer- type neuropathological changes accumulate gradually and virtually inevita- bly over the course of several decades (61). Adult Down s syndrome patients show cognitive impairment that is similar to early cognitive changes in Alzheimer s disease (62,63), and the time-course of neurofibrillary tangle formation in Down s syndrome displays regional patterns comparable to those observed in aging and Alzheimer s disease (64). These changes precede by decades the appearance of classic Alzheimer-type neuropathological changes. Head injury is now recognized as an important risk factors for the later development of Alzheimer s disease (67,68). These findings suggest that early glial inflammatory and neuronal acute-phase responses are important factors underlying the increased risk of Alzheimer s disease that follows head injury. In addition to these recognized risk factors for the development of Alzheimer s disease, there are other conditions in which the incidence of Alzheimer-type neuropathological changes has been shown to be increased. Epilepsy, for example, is not a recognized risk factor for Alzheimer s disease, although there is a small but significant increased risk of dementia in these patients (71). Patients with chronic intractable epilepsy show an accelerated appearance of Alzheimer-type "senile" neuropathological changes (72), and 80 Mrak and Griffin this is most striking in patients who carry the Alzheimer-associated ApoE 4 allele (73). The extent and pattern of neurofibrillary tangle distribution appear to be relatively predict- able (12), and these tangles preferentially affect a subpopulation of cortical neurons with long corticocortical projections (79). These corticocortical projections have been implicated in the distinct laminar patterns of neuritic plaque distribution within brain regions (12,80,81). Indeed, these corticocortical projection patterns suggest that transcortical spread of neuronal damage and loss in Alzheimer s disease may be engendered in remote target regions via corticocortical projections from damaged or dying neurons. Our results, showing progressive neuronal cell damage and eventual neuronal loss as plaques evolve from diffuse to more complex forms, suggest that plaque-associated neuronal injury is a major cause of neuronal cell injury and loss in Alzheimer s disease. According to our view, a subset of basic mechanisms in aging is equivalent to chronic inflammatory processes, which predispose to the deposition of amyloids in the brain and other organs. The term amyloid was introduced by Rudolf Virchow in the 1850s to describe starchy inclusion bodies in animals; for historical perspectives, see Schwartz (98), Pepys (85), and Sipe (104). Amyloids are most commonly characterized as fibrillar aggregates, which can be formed from diverse proteins and which have extensive `-sheet interactions as detected histochemically by the binding of the dyes Congo red or thioflavin-S (85,104). Some aggregated forms of the same protein are not recognized as amyloids because of the lack of histochemical signals for bound Congo red or thioflavin-S, e. Moreover, we have observed Congo red binding with a hyperchromic shift that is characteristic of `-sheet struc- tures in oligomeric, slowly sedimenting aggregates of A` (74). These examples indicate that the archaic term amyloid requires cautious use in its application to molecular structure and biological activity, because it may exclude many states in amyloid-forming proteins that are biologically interesting. These complex processes are subject to many modulations by genetic variations at multiple loci. They may also be sensitive to endogenous levels From: Contemporary Clinical Neuroscience: Molecular Mechanisms of Neurodegenerative Diseases Edited by: M. These multiple outcomes of aging give a strong basis for ultimate optimism, as we identify segments of these complex inflammatory processes that are ongoing during life in multiple organ systems. Senile plaque amyloids consist mainly of A` 1 42 but with some longer and shorter peptides, whereas cerebral blood vessels accumulate amyloid containing the slightly shorter A` 1 40. We note briefly that the accumulations of aggregated A` and hyperphosphorylated tau are extremely common during aging of primates and most other mammals that live longer than 10 yr (26,88). These and other species-generalized aging changes define a canonical pattern of aging in mammals (24). We emphasize that many other forms of aggregated A` 1 43 peptides are found widely during aging in many brain regions. These heterogeneous extracellular materials range widely in morphology and binding of Congo red, which is a required criterion for designation as an amyloid. Because of neurons with abnormal dystrophic neurites (swollen, twisted) that are nearby or growing though their matrix, senile plaques are also called neuritic plaques. Although the amorphous deposits may arise before the senile plaques, there is no information on causality. Louis) Alzheimer Center showed all those with minimal cognitive dysfunction had many neuritic plaques, whereas cognitively normal individuals of the same age had a much lower density of amyloid deposits (76). Although some authors emphasize that neurons tend to have normal morphology around diffuse plaques with loss of synapses (112), others have observed a smaller cholinergic neuron fiber density in nondemented elderly with diffuse A`-containing deposits, also consistent with early pathogenesis (7). Complex aggregates form rapidly during incubation of various A` peptides (A`1 40, A`1 42, A`25 35) at ambient temperatures; these high-molecular-weight aggregates have widely varying toxicity (102). However, work from this laboratory in collaboration with Klein and Krafft of Northwestern University has demonstrated that oligo- meric (soluble) A` aggregates are highly toxic to neurons (60,81). The neurotoxic pathways involve oxidative stress (8,60,81) and appear 90 Finch et al. Superoxide and redox-active iron are both implicated as mediators of A` neurotoxicity (8; Longo and Finch, unpublished). Inflammatory Processes in Amyloid Aggregates Besides the neurotoxicity of various forms of aggregated A` peptides, they may participate in inflammatory mechanisms at many levels (Table 1). By inflammatory mechanisms, we mean to include several subsets of the cellular and molecular changes observed in injured peripheral tissues. With its cold variety of inflammation, the brain may offer a unique opportunity to study complement functions independently of B- and T-cells. Microglia are bone-marrow-derived cells of the mono- cyte lineages that, like peripheral tissue macrophages, become phagocytic and produce reactive oxygen species. In general, fewer activated microglia are associated with diffuse A` deposits (15,87,93). A continuum of aggregation states is indicated, in which increased micro- glial and astrocyte activation parallels the intensity of thioflavin-S staining (15,87). Of particular interest, the activation of microglia appears to preceed that of astrocytes. Many inflammatory proteins are detected in senile plaques including cytokines, complement factors, and acute-phase proteins (Table 2). A general note of caution is that these histochemical observations are semiquantitative at best and are sensitive to fixation and to the specificity of the antibodies. Of great interest to inflammatory mechanisms, C1q shows strong immunostaining in senile plaques (1,22,91).

C cheap 25 mg imitrex overnight delivery spasms hands fingers, Removal Flaps that transect the streak canal should be clipped off of the ap restores teat function order generic imitrex pills spasms throat. Bruce Hull order cheapest imitrex and imitrex spasms everywhere, Professor of Large Animal Surgery at the sutured similarly to the repair of teat stulas described Ohio State University, the wound is made with a previously. All principles are identical to repair of a sur- manure-laden foot rather than a sterile scalpel. Careful debridement, aseptic techni- Treatment of brous or membranous obstructions at the que, carefully placed sutures, and absolute closure of base of the gland cistern is not likely to be successful. Use of indwelling cannulas follow- teat and gland cisterns has been successful rarely, but ing surgery will help decrease internal pressure on the most surgical interventions are unsuccessful. The cannula should be left open to drain con- of teat obstruction is as described in diffuse teat-cisternal tinually for several days. Temporary or permanent teat implants of- for 3 to 5 days, and the quarter is infused with antibiot- fer the best success rates for heifers and cows that have ics following repair. Success rates of 50% or more are likely for this type of teat obstruction when Blind Quarters and Membranous implants are used. Stenosis or atresia of the teat end is treated by slow Obstructions dilation of the streak canal when the canal can be seen Etiology or by sharp puncture of the apparent dimple at the teat Blind quarters appear to be laden with milk at freshen- end when a streak canal cannot be identied. Congenital or acquired lesions sharp 14-gauge needle is directed into the teat lumen at that impair milk ow from the gland cistern cause blind the apparent dimple that correlates with where the quarters. After needle puncture, genital, acquired before rst lactation, or acquired as a the stenosis can be opened further with a bistoury. Leaking Teats Degeneration of the gland cistern and connecting ducts is the most common lesion found in freshening Etiology and Signs heifers that have either small amounts or no milk from a Many cows leak milk just before normal milking times quarter that appears to be of normal size. The condition because of intramammary pressure; this is considered is thought to be caused by intramammary infection or normal or physiologic. Such infections can be and that which occurs at times other than milking or that initiated by aggressive nursing of incompletely weaned affects show potential is considered abnormal. At the time the blind quarter is identied, masti- Generally milk leaking is more common in previ- tis is usually not present in the affected quarter. The injury has disturbed normal sphincter tone or integrity of the teat end by brosis or Signs loss of tissue so that leaking occurs. Anticipated quantities of milk cannot usually be obtained from the affected quarter. The teat usually feels abby and Diagnosis meaty rather than turgid, as expected in normal milk ll- Only the history and physical inspection of the teat are ing. The teat may be probed to assess in cases in which congenital or acquired cisternal obstruc- the streak canal diameter but seldom is this necessary. Treatment Injecting about a drop of Lugol s iodine solution with a Diagnosis tuberculin syringe at four equidistant spots in the sphinc- Careful probing of the teat cistern and gland cistern with ter muscles has been reported to correct leaking in ap- a 3- or 4-in (7. This technique also allows assess- Skin Lesions ment of any teat-cistern obstruction and permits milk to be obtained for examination. If the diagnosis is still in Viral Causes question following probing of the quarter or if surgical Bovine Papillomavirus treatment is contemplated, ultrasound examination is Etiology. Salicylic acid (10%) and g spread primarily by milking machines and milkers tree latex applied every 5 days has also been shown to be hands that carry the virus, which then infects the skin in effective. Because of the current concerns about transmission Florid warts that appear as classical papillomas or bro- of prions among cattle, autogenous vaccines cannot be papillomas with epithelial projections may be more recommended. Warts at the teat end The use of common utensils during udder washing sometimes interfere with effective milkout and always and drying should be avoided; udders should be washed predispose to mastitis because of environmental con- and dried with individual paper towels before milking. Herds with endemic instances of this type of Herpes Mammillitis wart can be extremely frustrating because means to stop Etiology. If signs are not pathognomonic, excisional herds where the virus has persisted in recovered older biopsy is conrmatory. The exact means of spread is unknown because numbers of cattle are affected, freezing of the warts by rather deep inoculation of the virus into the teat wall is application of a steel rod chilled to liquid nitrogen required for experimental reproduction of the disease. Several authors suggest an insect mode of transmission, but this theory does not coincide with the peak seasonal (fall-winter) incidence. Types of early lesions vary but may include vesi- cles, edematous plaques, and serum crusts. Initially vesi- cles form on the skin of the teat and udder, and the skin appears edematous. Sizes of lesions range widely from a few millimeters to several inches in diameter and vary in number in infected cattle. After several days, dense crusts and dark-colored scabs cover the ulcerations and persist for 10 to 14 days until healing begins. Other useful tests include biopsy of early skin lesions and the edges of ul- cers to look for intranuclear inclusions that help differen- tiate the disease from pseudocowpox (intracytoplasmic inclusions) and syncytia formation. Some laboratories may offer serology because infection does confer detect- able serum antibodies. Supportive measures include careful milk- ing to minimize mastitis, application of softening creams to the teat lesions, use of iodophor teat dips to inactivate the virus, and milking affected animals last. Vesicles are present on the skin of from the vesicular uid of early lesions from herdmates the teat-gland junction at left, and ulcers and crusts are injected away from the udder probably may work well present on the teat and gland to the right. Dietary measures to control udder edema in rst-calf heifers during the winter months in endemic herds make intuitive sense and can lessen le- sion severity. The cause of pseudocowpox lesions on the teats of cattle is a member of the genus Parapoxvirus within the family Poxviridae. The pseudocowpox virus is very similar to the papular stomatitis virus and the virus that causes contagious ecthyma (orf) in sheep and goats. Pseudocowpox causes painful papules, vesicles, and de- nuded circular raised areas that heal under a thick scab. Cowpox or vaccinia are extremely rare the skin above the right hind teat, and the right front and currently may not be present in the United States. When cowpox or vaccinia is present, cows usually have become infected from a milker recently vaccinated against smallpox with the vaccinia virus. The lesions are the most severe skin lesions that erupt and then are covered by a thick scab. Once the le- autumn, should alert the veterinarian to the diagnosis of sion heals under the scab, it becomes proliferative and herpes mammillitis. Lesions usu- subsequently be lost or sold for salvage because of masti- ally heal within 2 to 3 weeks but may become chronic tis. Clinical signs, history, and diagnostic labo- then may disappear for a time, and then recur. Because of the public health signicance of pseudocowpox and the similarity to cowpox or vaccinia and exotic diseases, it is best to make a denitive diagno- sis through viral isolation from tissue or vesicular uid, or else electron microscopy should be performed on vesicle uid. Standard histopathology of a biopsy specimen may B show intracytoplasmic inclusions, but this will not iden- tify the exact poxvirus. Cattle should be examined for other mucosal disease lesions if illness accompanies the teat lesions because pseudocowpox is not associated with systemic illness. There have been several outbreaks of teat lesions resembling pseudocowpox in cattle for which a denitive diagnosis could not be reached. Efforts to reduce teat abrasions and to milk affected cows last may or may not be possible.

This may be the formation is unknown in cattle but is inherited in trapezoid body and the cochlear nuclei in an abnormal laboratory rodents generic 25 mg imitrex otc muscle relaxant names. Clinical signs will be prosence- position that cannot be explained by an in utero viral phalic purchase imitrex 25 mg on line muscle relaxant tizanidine, but brainstem and cerebellar signs may be infection buy imitrex cheap online spasms under belly button. The fourth ventricle is remarkably reduced present if there is signicantly increased intracranial in size. In the head, the cerebellum is attened and elongated into a cone-shaped structure, and it is dis- placed into the foramen of the atlas and cranial axis along with the medulla. There is a bilateral abnormal extension of each occipital lobe into the cau- dal cranial fossa space vacated by the cerebellum. These abnormal extensions of the otherwise normal occipital lobes pass ventral to the tentorium, which results in a groove on the lateral side of each of these extensions. Partial Diprosopus/Dicephalus Meningoencephalocele Occasionally calves are born with partial duplication of This malformation occurs along the midline of the cal- the face (diprosopus). This usually consists of varying varia through an opening referred to as cranioschisis or degrees of two separate nasal regions; therefore four na- cranium bidum. The cranial region is broad, but there are it is possible that some of these malformations may just two normal ears and a single normal atlantooccipital be meningoceles, microscopic study of the tissues con- joint. Two diencephalons These also can occur along the midline of the calvaria or are present (one for each set of eyes, two pairs of optic vertebral column through a cranioschisis or spina bi- nerves, and two optic chiasms). They consist of fat-lled meningeal becomes single somewhere in the mesencephalon. The tissue continuous with the falx cerebri in the head or the pons, medulla, and cerebellum are single structures. These calves are usually born alive neural tube malformation, there are no neurologic signs but are recumbent and unable to stand. Prosencephalic Hypoplasia-Telencephalic Aplasia Complex Nervous System Malformation Calves with this sporadic unique malformation are alive A unique multifocal bone and neural tube malforma- at birth and unable to stand. Their cranium is attened tion described in calves has been called an Arnold-Chiari between two normal orbits with normal eyeballs. A dor- malformation, presumably because of an assumed simi- sal midline skin defect is present at the level of the cau- larity to a human malformation given this eponym. These calves are usually born recumbent and tinuous caudally with a malformed diencephalon at the unable to coordinate their limb and trunk function to rostral portion of the brainstem. They often exhibit opisthotonos and abnormal hemispheres, just a malformed brainstem and cerebel- nystagmus. There is no Although meningitis is a sporadic disease on well- adequate term for this combination of malformations, managed farms, endemic problems may develop when and we have chosen to call this prosencephalic hypopla- calf husbandry is poor. The cause is unknown in negative or less commonly gram-positive bacteria seem cattle but has been blamed on folic acid deciency or to result in meningitis in a high percentage of calves that hyperthermia in humans. This outbreak Failure to develop normal central nervous system represents the rst time that we have seen E. An inherited radic cases of meningitis in adult cows have been caused hypomyelinogenesis has been reported in Jersey calves. The foci of chronic infection such as traumatic reticuloperito- more excited the calf becomes and struggles to move, nitis abscesses. It disappears when the calf is mon predisposing cause of sporadic bacterial meningitis completely relaxed. When multiple cases of Axonopathy acute meningitis occur within a herd of adult cattle, His- We recently studied a group of related Holstein calves tophilus (Haemophilus) somni infection should be sus- that at birth were usually able to stand and walk but had pected. When Etiology meningitis precedes other major organ infection, signs of Gram-negative septicemia in neonates is the most com- fever, depression, head pressing or headache appear- mon cause of meningitis in dairy cattle. The gait is stiff, and the head is often held cient levels of passively acquired immunoglobulins to straight, with the muzzle extended. Septicemia may origi- ful, and the animal may appear to have a headache with nate in umbilical infections or more commonly by oral the eyelids partially closed and the head and neck ex- inoculation of pathogens. The heifer was treated with ampicillin and supportive treatment and recovered in 1 month. A 10-day-old Holstein calf with bacterial meningitis caus- ing severe opisthotonos. Depression Adult cattle affected with meningitis usually have fe- is so severe that presence or absence of vision may be ver and profound depression. A stiff, stilted gait and difcult to determine, and occasional seizures are ob- headache appearance (stargazing or continually press- served in some patients. Affected cows die within 24 to ing head or muzzle against an object) are common 48 hours of onset unless treated specically for H. Inammation of the visual cortex can result in tiple cases over a period of several months, until appro- blindness with normal pupillary function. Treatment Broad-spectrum antibiotics constitute the primary treat- ment for meningitis in calves and adult cattle. For example, in neonatal calves, the antici- pated cause would be a gram-negative organism such as E. Although not permitted in North Focal chorioretinitis with hemorrhage dorsal to the optic America, enrooxacin would be an excellent antimicro- disc in a Holstein yearling with thrombotic meningoen- bial selection for gram-negative meningitis. In subacute cases, calves that are aggressively treated too late with proper macrophages may predominate. The uid can appear antibiotics may live for several days but never regain normal on visual examination, or it can be grossly discol- reasonable mentation and have necrotic lesions in the ored (red to orange). Serum pro- life-threatening inammation and cerebral edema associ- tein and immunoglobulin levels should be evaluated in ated with meningitis. Seizures may be controlled with meningitis secondary to acute or chronic infections 5 to 10 mg of diazepam in neonatal meningitis patients. These cattle have been ill for variable lengths of time, and the developing signs of Prevention meningitis may be mistakenly assumed to be progres- Adequate passive transfer of immunoglobulins through sive systemic illness associated with failure to respond well-managed colostrum feeding of each newborn calf to therapy for the primary condition. In addition, direct extension from chronic frontal sinusitis and bacterial seeding as- sociated with nose rings in bulls are other potential causes of brain abscesses in adult cattle. Although the relationship with frontal sinusitis is obvious, the in- ferred higher risk of cattle or bulls with nose rings for brain or pituitary abscesses is very interesting. Theories to explain this phenomenon center around the complex rete mirabile circulation that encircles the pituitary re- gion and is suspended in the cavernous sinuses, which drain the nasal cavity. Arcanobacterium pyogenes is the most common organism isolated from brain abscesses in cattle. As the abscess enlarges, varying degrees of visual when walked in a tight circle or over rough ground. If the abscess fected cattle continue to eat despite extensive space- becomes sufciently large, it will interfere with venous occupying abscesses. Antiinamma- Depression and a stargazing attitude have been observed tory or antibiotic therapy may stabilize or transiently in cattle with cerebral abscesses. Bradycardia coupled improve the animal s signs, but regression coincides with depression and a stargazing attitude has been de- with stoppage of medications. The bradycardia may result from involvement of hypothalamus or may be caused by the anorexia. Diagnosis Abscesses localized to one cerebral hemisphere usu- Antemortem conrmation of brain or pituitary ab- ally cause blindness with intact pupillary function in the scesses may be difcult.

Severe thrombocytopenia or contin- tion buy 25 mg imitrex spasms 1983 youtube, moderate to severe anemia may be apparent result- ued bleeding dictates replacement of clotting factors ing from internal or external blood loss and is apparent even though this may provide further substrate for on- based on mucous membrane pallor buy imitrex 25 mg visa muscle relaxant quiz, elevated heart rate order imitrex 50mg otc muscle relaxant and pain reliever, going coagulation. Hypoproteinemia also is more likely in the eld, fresh whole blood may be indi- present when blood loss has been severe. Rodenticides such as warfarin and brodi- plastin time support the diagnosis when no other clot- facoum that are coumarin derivatives, coumarin- ting abnormalities are identied. The absence of biochemical evidence have become moldy or sweet vernal grass, and diffuse of hepatic failure rules out liver diseases. All affected animals should receive vita- Peracute abomasal hemorrhage without obvious min Kl (1. Arterial and venous thrombosis are generally associated Vitamin K3 is not a substitute for Kl and in fact may with septic causes, e. Most vitamin K3 products (menadione so- thrombosis; jugular and vena caval thrombosis associ- dium bisulte) have been taken off the market because ated with septic phlebitis; uterine, mammary, or intesti- of toxicity to domestic animals and humans. Roden- Endocarditis may result in thrombosis of renal or pulmo- ticides should be managed carefully to avoid accidental nary arteries. Sudden death resulting from exsanguination may result in cattle from a variety of causes. In Proceedings: 6th Annual Veterinary Medicine Forum (American College Veterinary Internal Medicine), 175-177, 1988. In Proceedings: 16th Annual of the induced arrhythmia with atropine, Am J Vet Res 37: Convention American Association Equine Practitioners, 383-388, 1970. The increased resistance to airow caused by upper airway obstructions often creates audible inspiratory noise and results in referred airway sounds through the tracheo- bronchial apparatus. Sounds that have been referred to the lower airway from an upper airway obstruction may be misinterpreted as lower airway in origin unless the upper airway is examined and the trachea ausculted in such cases. If the respiratory sounds can be heard without a stethoscope, they are most likely originating from the upper respiratory tract. The upper airway examination should include detection of airow from both nostrils, close examination of soft tissues of the head, and oral examination if necessary. Holstein with retropharyngeal abscessation and pain associated with iatrogenic trauma. Simple drainage or drainage with cau- formations, and branchial cysts have been observed in tery of cystic lesions is not likely to be successful. Inspiratory dyspnea with audible fore referral of such cases to veterinary surgeons experi- snoring sounds or stertorous breathing is a sign common enced in upper airway surgery is recommended so that to most of these problems. The condition may be present complete excision of the secretory epithelium can be at birth or is most often observed within the rst few completed. The degree of dyspnea associated with mations and skull anomalies have a poor prognosis. In restraint is a frequent, and potentially fatal, error in addition, aspiration for cytology and cultures may be in- judgment made by inexperienced clinicians. Most cystic lesions will be sec- a dyspneic animal struggles during examination, usu- ondarily infected. Although the prognosis for congenital lesions var- ies with the specic diagnosis, generally it is guarded to poor. Most of the lesions represent en- sinusitis or unilateral neoplasms of the nasal pharynx or largement or inammation of tissues and structures maxillary sinus. Unilateral Horner s syndrome and progres- enlarged lymph nodes, neoplasms, foreign bodies, or sive exophthalmos have been observed in slow-growing enlarged maxillary sinuses compose the majority of le- adenocarcinomas of respiratory epithelial origin in the sions. Cattle with unilateral nasal probably the most common acquired causes of ob- obstruction often show more obvious respiratory signs struction. The owner may report a progressive course of is the primary sign observed in affected cattle. Fever may stertorous breathing eventually leading to open mouth be present with pharyngeal abscesses or chronic maxil- breathing. Unilateral nasal discharge or reduced air- acute course than neoplasms, but this is a generality ow from one nostril may be present with maxillary rather than a rule. This edema should not be misinterpreted as the causative lesion (see video clips 3 to 5). Skull radiographs may be necessary if physical exami- nation and endoscopy fail to identify a lesion. Radio- graphs are helpful for denitive diagnosis of sinusitis, nasal or sinus cyst, and for identifying the location of soft tissue masses such as abscesses or tumors. In addi- tion, radiographs would help to identify abscessed tooth roots in cases of chronic maxillary sinusitis and metallic foreign bodies. Diagnostic ultrasonography, if available, may help in the assessment of soft tissue swellings. The mass caused reduced airow through In the case of obvious or palpable swellings of the the left nasal passage, left-sided Horner s syndrome, and head or pharynx, aspirates for cytology and culture are exophthalmos. Treatment is most suc- cessful when external compression of the upper airway can be cured through treatment of an inammatory lesion. Pharyngeal or retropharyngeal abscesses should be drained with liberal incisions that avoid vital struc- tures. External drainage is techni- cally difcult in deep pharyngeal abscesses located more than a few centimeters below the skin surface. Vagus nerve damage, salivary duct laceration, and acute celluli- tis are potential complications associated with opening the abscess. If recurrence is obvious, culture and sensitivity coupled with drainage through multiple sites are indi- cated. A complete physical examination fol- disinfectants or sterile saline, and appropriate systemic lowed by manual and visual inspection of the oral cav- antibiotics for 1 to 2 weeks. Relative equality of In general, neoplasms have a hopeless prognosis, and airow and the odor of the breath should be evaluated the animal should not be treated. If chronic maxillary sinusitis is suspected, coma often causes upper airway dyspnea via enlarged the upper premolar and molar teeth should be exam- pharyngeal lymph nodes. Signs include a progressively enlarging mass in fore unlike cattle with lymphosarcoma, these animals one nostril and inspiratory dyspnea as the lesion en- may be allowed to survive for some time to deliver an- larges to occlude the nostril completely. The granulo- other calf or to undergo superovulation and embryo mas may originate at the site of nose-lead lesions of the transfer. Only if the animal stops eating, develops severe mucosa near the nasal septum or at other mucosal sites respiratory distress, or is suffering from exposure damage of soft tissue injury from foreign bodies or brous feed. Actinomyces bovis originating in a sinus, bone, or periocular location occa- was responsible for multiple tracheal granulomas in a sionally may have enough tumor mass or lymph node cow treated at our clinic. Granulomas can be confused with tu- squamous cell carcinomas frequently have a fetid breath mors on gross inspection. Therefore diagnosis requires odor from the primary tumor and should not be made to biopsy for histopathology and tissue culture. Although usually found near the external nares, granulomas caused by Inammatory Diseases Allergic Rhinitis Also called summer snufes, allergic rhinitis occurs pri- marily in cattle turned out on pasture in the spring and summer.