By R. Hamid. Vermont Technical College. 2019.
Each prosthetic valve is inherently stenotic and thus has a higher than normal peak velocity across it order lasuna 60 caps with amex cholesterol lowering foods mercola. The continuous-wave Doppler gradient across the prosthesis obtained 4 to 6 weeks following implantation serves as a baseline for subsequent evaluations order cheap lasuna on line cholesterol medication grapefruit juice. High gradients may also be obtained in nonobstructive situations purchase lasuna now cholesterol krill oil, such as high-output states, tachycardia, anemia, severe prosthetic leaks, or from the pressure recovery phenomenon. Pressure recovery occurs secondary to flow acceleration through a narrowed orifice, especially in the central orifice of a bileaflet valve in the aortic position. In this setting, the highest pressure measured through the prosthesis by Doppler overestimates the true pressure gradient by approximately one-third, and manufacturers take into account pressure recovery when determining normal gradients. Calculation of orifice area in prosthetic valves is difficult given the complexity of the orifice (struts/disks), especially in mechanical prostheses. The pathologic flow disturbance is larger and wider than that seen with physiologic regurgitation. Pathologic regurgitation may be related to calcified and fibrosed leaflets, disruption of the sutures securing the valve, or a perivalvular abscess with adjacent tissue destruction. The image intensifier is moved to a position with x-rays parallel to the valve ring plane to determine the occluder’s excursions in a caged valve. Despite the radiolucency of pyrolytic carbon disk valves, the opening angle can be measured from positioning the image intensifier parallel to the plane of the open leaflets. However, catheter-based evaluation of the mechanical aortic valves should be performed with a transseptal technique. Transseptal access may also be necessary for accurate measurement of prosthetic mitral valve gradients, because catheter-based assessment overestimates the mitral valve gradient because of a dampening of the pressure contour and intrinsic delay in the pulmonary capillary wedge tracing. However, dedicated sequences can provide information about blood flow velocities and regurgitant fractions. Up to 50% of patients undergoing valve surgery experience postoperative atrial fibrillation. In patients without a previous history of atrial fibrillation, the arrhythmia is often self-limited. For patients with persistent atrial fibrillation beyond 24 hours, anticoagulation, direct current cardioversion, and a short course of antiarrhythmic therapy can be considered. High-grade heart block requiring permanent pacemaker implantation has been described in 2% to 3% of patients after valve replacement and 8% following repeat valve surgery. It is caused by trauma to the bundle of His or from postoperative edema of the periannular tissue. Aortic or mitral annular calcification, preoperative conduction disturbance, advanced age, and infectious endocarditis are associated with higher rates of postoperative conduction abnormalities, leading to permanent pacemaker implantation. Approximately 3% to 6% of patients with prosthetic heart valves will experience prosthetic valve endocarditis. Early prosthetic valve endocarditis (<60 days following implantation) is typically caused by Staphylococcus epidermidis. Late prosthetic valve endocarditis has a microbiology similar to community-acquired native valve endocarditis. Medical cure for prosthetic valve endocarditis caused by staphylococci, gram-negative organisms, or fungi is rare. Streptococcal prosthetic valve endocarditis responds to medical therapy alone in 50% of cases. A high index of suspicion should be maintained for the presence of residual infection, and surgical reevaluation should be considered if medical treatment fails. Subclinical hemolysis is present in many patients with mechanical valves but rarely results in significant anemia. Clinical hemolysis occurs in 6% to 15% of patients with caged ball valves but is uncommon with normal bioprosthetic or tilting disk valves. Clinical hemolysis is also associated with multiple prosthetic valves, small prostheses, periprosthetic leaks, and prosthetic valve endocarditis. Mechanisms involved in the generation of hemolysis include high shear stress or turbulence across the prosthesis, interaction with foreign surfaces such as cloth, and rapid deceleration of erythrocytes following collision with adjoining structures (e. Diagnosis is made by elevated lactate dehydrogenase, reticulocyte count, unconjugated bilirubin, urinary haptoglobin, and presence of schistocytes on blood smear. Echocardiographic findings consistent with mechanical hemolysis include abnormal rocking of the prosthesis or regurgitant jets of high shear stress (e. Mild hemolytic anemia can be managed with iron, folic acid supplement, and if needed, blood transfusion. Paradoxically, treatment of the anemia may reduce the degree of hemolysis by limiting the need for high flow through the defective valve. Repair of perivalvular leaks or valve replacement is indicated in patients with severe hemolysis requiring repeated transfusions or in those with congestive heart failure. Percutaneous approaches can also be considered, but are not feasible with extensive dehiscence or when there is active infection. The incidence is highest in the tricuspid position, followed by the mitral and then the aortic position. Thrombus is suspected in patients with an acute onset of symptoms, an embolic event, or inadequate anticoagulation. Echocardiographic features suggestive of thrombus include an irregular and mobile mass. Fibrinolytic therapy has an initial success rate of 82%, overall thromboembolism rate of 12%, and a 5% incidence of major bleeding episodes. For left-sided valves, there is a similarly high success rate (82%) with fibrinolytic therapy; however, the associated risks of death (10%) or systemic embolism (12. Thrombolysis should be considered for left-sided valves in patients with contraindications to surgery. Thrombolysis may be a reasonable alternative to surgery for mitral or aortic prosthetic valve thrombosis in patients with a small thrombus burden. A: Layering thrombi on the nonflow side of stented bioprosthesis; B: A ring of pannus on the flow side (subvalvular) of a stented bioprosthesis; C: Nodular cuspal calcifications of a stented bioprosthesis; D: Leaflet teat of a stented bioprosthesis; E: Thrombosed bileaflet mechanical valve; F: Subvalvular pannus ingrowth of a bileaflet mechanical valve. The risk profile of the individual patient must be balanced against the expertise and experience at each center. Detachment of the sewing ring from the annulus may occur in the early postoperative period because of poor surgical techniques, excessive annular calcification, chronic steroid use, fragility of the annular tissue (particularly following prior valve operations), or infection. Abnormal rocking of the prosthesis on echocardiography is an indication for urgent surgery. All prosthetic valves, with the exception of stentless aortic homografts, have effective orifices that are smaller than those of native valves. There is an inherent pressure gradient and relative stenosis with each prosthesis. Depending on the definition and surgical series used, this mismatch may occur between 20% and 70% of cases after aortic valve replacement. In a patient with a small annulus, a hemodynamically favorable prosthesis like a stentless bioprosthesis, aortic homograft, or a tilting disk valve is preferred. Alternatively, the aortic annulus may be enlarged surgically in order to accommodate a prosthesis of acceptable size. Aortic prostheses <21 mm in diameter are not recommended for a large or physically active patient.
To the contrary cheap 60caps lasuna overnight delivery cholesterol lowering foods indian diet, clinical and public health eth- ics oblige extending equivalent access to quality therapeutic and preventative health care to all individuals lasuna 60 caps for sale cholesterol emboli syndrome definition. Where food is lacking generic lasuna 60 caps fast delivery cholesterol test gp, it becomes impossible to live with dignity, and the rights to a healthy life and peaceful coexistence are undermined. Food insecurity at the household level has become an increasing public problem with increasing wealth inequality  and intermittent infation of staple food prices . Worldwide, 925 million people, or 14% of the world’s population, are undernour- ished . Overall, women and children account for the highest proportion of the chronically hungry. Rates of obesity are increasing worldwide, not only in adults but also in children. In addition, >40 million children under the age of 5 years were overweight in 2010 . Poverty is also seen as a strong risk factor for excessive weight because quality foods are beyond the means of the poor. Malnutrition has become a signifcant impediment to development in rich and poor countries alike. At the individual level, both hunger and obesity can reduce a person’s physical ftness, increase susceptibility to illness, and shorten life span. In addition, children deprived of adequate nutrients during development can develop permanently reduced mental capacity. At the national level, poor eating hampers educational performance, curtails economic productivity, increases the burden of health care, and reduces general well-being. Confronting this epidemic of poor eating will have widespread benefts; however, policy responses have been wildly off the mark in addressing the problem. Efforts to eliminate hunger often focus on technological quick fxes aimed at boosting crop yields and producing more food rather than addressing the socioeconomic causes of hun- ger, such as meager incomes, inequitable distribution of land, and the disenfranchise- ment of women. Efforts to reduce overeating single out affected individuals—through fad diets, diet drugs, or the like—while failing to promote prevention and education about healthy alternatives in a food environment full of heavily marketed, nutritionally suspect, “supersized” junk food. The result: half of humanity, in both rich and poor nations, is malnourished today, despite recent decades of global food surpluses . The pathogen specifcity and the immune mechanisms have emerged as interest- ing, as discussed below. Perhaps equally entrenched is the concept that frail per- sons were more likely to succumb to infections. It turns out that this is nuanced in terms of characteristics of infection such as initial susceptibility, duration, and severity. Challenging to logic on frst instance is how having fewer nutrients could be protective against infection; however, ample evidence for this phenomenon, and its mechanisms, are emerging. Even the strange interaction in the lower right-hand quadrant, of infection enhancing nutrient status, has gained substantiation over the decades. This is not diffcult to rationalize given the concentration of nutri- tional science and public health in the post-war and decolonization period on the situations in low-income countries of Africa, Asia, and Latin America. These concerns ft nicely into the “undernutrition” paradigm of the matrix in Box 4. It was not until the worldwide pandemic of overweight and obesity, frst recognized in developed countries in the late 1990s , came into prominence that an even more comprehensive and complex dimension to the infection– malnutrition interaction became evident. In the new millennium, the public health imperative to understand malnutrition in all of its forms, i. The burden of overweight was frst recognized in affuent nations, and among the affuent elite of developing societies . On the epidemiological front, however, the concept of transitions, specifcally “epidemiological transition”  and “nutrition transition” , would emerge in a sequential manner to complicate the panorama. With respect to the nutritional status of populations, problems of defcit and defciency persisted as public health problems in low-income settings, keeping the paradigm of Box 4. However, the poor of the world were also becoming overweight and obese within the broader framework of malnutrition, presenting the more challenging pan- orama for evaluation and response. In general, we fnd that problems of under- and overnutrition often coexist, refecting the trend in which an increasing proportion of people con- sume the types of diets associated with a number of chronic diseases. Through the frst half of the 20th century, undernutrition and infection were the main drivers of morbidity and mortality in Africa, Asia, and Latin America, and life 64 Nutrition–Infection Interactions and Impacts on Human Health expectancies were low. On these continents, few lived deeply enough into middle and late adulthood to worry about noncommunicable, degenerative diseases. Today, only in Africa is infectious death more common than that from noncommunicable diseases. One can conclude that the infection part of the interaction is receding from historical dimen- sions, while what remains confronts its traditional counterpart in undernutrition and a new partner in overnutrition and nutrient excess, all in the subtropical and tropical and socioeconomically deprived continents. As infection per se becomes a less important sector of the mortality panorama, the epidemiology of lethal infections is undergoing constant change. Small pox, measles, pneumonia, meningitis, poliomyelitis, diphtheria, pertussis, typhoid, yel- low fever, leprosy, tuberculosis, schistosomiasis, cholera, and malaria represent a litany of classic lethal transmissible diseases for which either immunizations, anti- microbial therapy, or both emerged and became generalized during the 20th century. It is, however, the domains of the “emerging” infectious diseases and to some extent “reemerging” infections, notably tuberculosis and malaria from the previous list, which are escaping from the traditional control measures through drug resistance [22,23], that confront the imbalances in nutritional status, and to some extent play out on a stage that includes developed and developing countries alike. This includes the experience of infections as promoting nutrient defciency, on the one hand, and undernutrition, related to def- ciency of macronutrients or micronutrients, to predisposing to more infections or more serious consequences of infections, on the other hand. Obviously, not all pathogens affect the same organisms, nor do infectious processes equally affect all nutrients. The interactions have been exhaus- tively catalogued since 1968, and it is not the intention here to reproduce the entire litany. Nutritional defcien- cies derive from lack of intake, maldigestion and malabsorption, excessive wasting, poor utilization, and increased requirements , and all of these can act alone or in combination in the prodrome, active period, and convalescence of infections. For Infection–Nutrition Interaction 65 example, intestinal infections reduce appetite, impair uptake systems, and enhance fecal excretion . Concerning the pathogenesis in this context, it ranges from decreased intake due to margination, loss of appetite, and oral candidiasis, to intestinal infec- tions such as intractable Cryptosporidium diarrhea to the cachectic effects of proin- fammatory cytokines . Febrile illnesses, with the activation of the acute-phase response, can even lead to excessive renal loss of nutrients that do not usually pass in the urine, such as vita- min A . This latter fnding, fnally, is similar to observations in some, but not all, settings for intestinal colonization with the protozoal organism, Giardia intestinalis . Respiratory and gastrointestinal infections are the most common childhood infectious illnesses worldwide. Beginning in the 1970s and consistently shown to the present has been the pervasiveness of infectious diarrhea as a factor in growth retardation . As nutritional impairment is a risk factor for diarrhea, it required prospective studies to disentangle the two-way interaction. The adverse nutritional effects can readily be explained by impaired absorption and transintestinal wasting of nutrients . Certain parasites that inhabit the lumen of the intestine have a high requirement for iron for their growth and reproduction. Among these are Entamoeba histolytica in the protozoan family, and hookworm (Ancylostoma duodenale, Necator ameri- canus) and whipworm (Trichuris trichiura) among the nematodes. These organisms obtain their iron by ingesting red blood cells of the host and provoke additional bleeding to gain access to the mucosal blood vessels.
In normal clinical circumstances buy cheap lasuna 60caps cholesterol levels 40 year old male, this is tolerable uses two wavelengths buy discount lasuna 60 caps line cholesterol lowering foods wine, because it needs to distinguish because values below 90% would be acted upon 60caps lasuna overnight delivery cholesterol biosynthesis. Ideally the two wavelengths used haemoglobin species, oxygenated and deoxygenated hae- should correspond to those at which absorptions of both moglobin, to calculate functional saturation. This means that the the nose or the forehead24 and the more peripherally pulse oximeter may give a falsely high SpO in smokers, 2 333 Ward’s Anaesthetic Equipment ac dc ac ac ac dc dc dc 660 nm 940 nm 660 nm 940 nm A Raw transmission signal Processed transmission signal with dc components equal 100 85 16 0 L = ac /dc 0 1. Reproduced from Magee P, Tooley M (2005) The physics, clinical measurement and equipment of anaesthetic practice. Clearly a pulse signifcantly in the waveband of interest; therefore, jaundice oximeter should not be used to assess the oxygenation of does not affect the accuracy of the pulse oximeter. Both foetal a patient who has suffered from carbon monoxide poison- haemoglobin and bilirubin, however, affect the accuracy of ing. Skin pigmentation does drugs including local anaesthetics and nitrates, resembles not usually affect accuracy, but some dark nail polish does. Only a co-oximeter Intravenous dyes, such as methylene blue and indocyanine with a minimum of four wavelengths can distinguish these green, alter the absorption spectrum of haemoglobin in the four species, to calculate fractional saturation. If vascular tone is markedly altered, then there is some Pulse oximeters are also prone to error in the presence of limitation to the accuracy of pulse oximetery. This applies movement and vibration,34 or electromagnetic interference to hypertension or vasoconstriction induced by cold27 or from ambient light, diathermy or mobile telephones. Anaesthesia and surgery Foetal haemoglobin has the same properties of light both militate against this by tending to allow body tem- absorption as adult haemoglobin within the wavebands perature to fall and recovery to be delayed after prolonged being discussed, so the pulse oximeter should be as accurate surgery (see also Chapter 30). Bilirubin does not absorb light nant hyperthermia is a potentially fatal condition caused 334 Physiological monitoring: principles and non-invasive monitoring Chapter | 14 | by some anaesthetic drugs in patients pharmacogenetically predisposed to it. A traditional way of measuring the temperature of a patient is to use a glass thermometer. The glass bulb is placed against the tissue where tempera- ture needs be measured, causing the fuid contained therein to heat up to the same temperature as the tissue. The resultant expansion of the fuid causes it to move into the calibrated glass tube as a column. The temperature can be read off the tube at the point where the head of the fuid column stops. A constriction is placed at the base of the tube so that when the bulb temperature drops and the bulb fuid contracts, the fuid column breaks allowing the fnal reading of the thermometer to be maintained. Mercury is frequently the fuid used as its expansion characteristics allow it to cover a wide range of tempera- tures. This is the Seebeck effect, and is the basis A thermistor is a semiconductor device whose electrical of thermocouple function. It is the basis of both the nasopharyngeal tempera- series of thermocouples (thermopile), detect the infrared ture probe35and some tympanic membrane thermometers. They have been between the two ends proportional to the difference in shown to demonstrate hysteresis and are sensitive to temperature between them, although the relationship is a draughts. Circuits, devices and systems: adverse event rate in high risk displays; a systematic review. Controlling data fow characteristics of peripheral nerve standards of monitoring during enhances anesthesiology’s role in stimulators. Casati A, Squicciarini G, Baciarello Pulse oximeter as a sensor of fuid Ezri T, Gebhard R. Crit noninvasive blood pressure device clinical comparison with Care 2005;9:429–30. Anaesthesia Effects of tissue outside of arterial Auscultatory measurement of 1991;46:291–5. Comparison of four pulse evaluation of four instruments and Comparison of indirect and direct oximeters: effects of venous fnger probes. Br J Anaesth 1990;65: methods of measuring arterial occlusion and cold induced 564–70. Effect of reliable surrogate measure of core indirect blood pressure peripheral vasoconstriction on temperature. Clinical pressure measuring devices: photoplethysmographic waveform evaluation of liquid crystal skin recommendations of the European and systemic vascular resistance. Respiratory gas sampling 337 Following a step change in the gas concentration, delay Gas concentration monitoring 338 in response time of the analyzer is due to two factors. The frst is the delay time or transit time: the time it takes for the Measurement of respiratory volumes 346 sample to get from the patient’s airway to the gas analyzer. Blood gas analysis 346 The second is the response time or rise time of the analyzer. Gas analysis during anaesthesia requires continuous The response time is usually considered to be the time monitoring of respired gasses and at times, intermittent taken for an analyzer to respond to within 90–95% of an sampling of blood gasses. A step change can cribed in this chapter utilize various physical or chemical be produced in one of three ways: by moving a gas sam- properties of the gas molecules, to detect and quantify the pling tube rapidly into and out of a gas stream; by bursting gas. As with all clinical measurement techniques, it is a small balloon within a sampling volume containing a important to understand the principles on which the gas gas sample; or by switching a shutter to a gas sample analyzers are based, so that their applications and limita- volume using a solenoid valve. Most modern analyzers use side stream sampling, where the sampling tube takes the gas sample to the analyzer. Gas analyzers sample gas at a rate of volatile anaesthetic agent and ensuring adequacy of venti- between 50 and 200 ml min−1. If the sampling rate is lation by capnography, which also gives some information higher than this, or if the tubing is too long or too wide, about the circulation. Common to all methods is the delay in the sampling rate and on the length of the sampling tube, sample reaching the analyzer and the response time of the which should be as short as possible. Also, not all analyzers return the sample In trying to sample gasses at the end of expiration, it is to the breathing system. This is advantageous when the important to sample as close to the patient’s trachea as gas analyzer alters the integrity of the gas molecule. Most systems, however, have a sampling port attached to the breathing system adjacent to the artifcial airway. It is still possible, however, for a gas sample, vapour), the other which is of otherwise identical constitu- taken, for example, from the patient end of a coaxial tion (e. The refractive index of a medium is a Mapleson D breathing system, a type of T-piece, to give measure of the ratio of velocity of light in a vacuum to the erroneously low end tidal readings, due to confusion velocity of light in that medium. This is a bulky addition to the airway gas medium depends on its concentration, pressure and but it eliminates transit time, and is reported to be more temperature. When a light beam passes through parallel useful in detecting sleep apnoea than sidestream analyz- slits whose width is of the same order of magnitude as the ers. An example is the Hewlett Packard infrared out of phase (dark fringe) with each other.
In low-risk populations lasuna 60caps low price cholesterol jones and his band, polyarthritis fulfills the arthritis criteria discount lasuna 60caps visa cholesterol levels while losing weight, whereas in high-risk populations order generic lasuna line cholesterol friendly foods, either polyarthralgia or monoarthritis and/or polyarthritis can be considered. Also known as Saint Vitus dance or chorea minor, this extrapyramidal disorder is characterized by purposeless and involuntary movements of face and limbs, muscular hypotonia, and emotional lability. Most cases tend to follow a benign course, with complete resolution of symptoms in 2 to 3 months, although cases in which symptoms persisted for >2 years have been reported. Differential include tics, athetosis, conversion reactions, hyperkinesia, and behavioral abnormalities. The skin overlying the nodules is freely mobile and shows no signs of discoloration or inflammation. This is an evanescent erythematous macular rash with a pale center of irregular shape. It is highly specific, occurring in <5% of patients, and is obvious only in fair-skinned individuals. Fever is encountered during the acute phase of the disease and does not follow a specific pattern. Arthralgia is defined as pain in one or more large joints without objective findings of inflammation on physical examination. Supporting evidence includes onset approximately 3 weeks following an upper respiratory tract infection, rarity before the age of 5 years when the immune system is still immature, and cross-reactivity between streptococcal cellular antigens and proteins present in human connective tissue. The most important antigenic structures (M, T, and R proteins) are localized in the external layer of the bacterial cell wall. The M protein not only is responsible for type-specific immunity but also has a powerful antiphagocytic action and is classically regarded as a marker of streptococcal rheumatogenic potential. A slide agglutination test is commercially available, which measures antibodies to several streptococcal antigens. Aschoff nodules, a form of granulomatous inflammation, can be seen in the proliferative stage and are considered pathognomonic for rheumatic carditis. Such nodules are most often found in the interventricular septum, the wall of the left ventricle, or the left atrial appendage. The histologic findings of endocarditis include edema and cellular infiltration of valvular tissue. Hyaline degeneration of the affected valve results in the formation of verrucae at its edge, preventing the normal leaflet coaptation. If the inflammatory process persists, fibrosis and calcification develop, leading to valvular stenosis. Endomyocardial biopsy does not help in diagnosing first attacks of rheumatic carditis. It is useful in distinguishing chronic inactive rheumatic heart disease from acute rheumatic carditis. As such, it is rarely indicated except in cases where recurrent carditis is suspected but cannot be confirmed otherwise. As in any inflammatory process, leukocytosis, thrombocytosis, or hypochromic or normochromic anemia may be noted. Although these tests are nonspecific, they may be helpful in monitoring the inflammatory activity of the disease. Chest radiography may identify increased cardiac size, increased pulmonary vasculature, or pulmonary edema. Calcifications of the leaflets and subvalvular apparatus are present in the chronic, not acute, phase of rheumatic heart disease. Echocardiography/Doppler findings not consistent with carditis should be excluded in the diagnosis of a patient with a murmur. Transesophageal echocardiography should be considered if obtaining adequate images are difficult with transthoracic echocardiography particularly paying attention to the mitral and aortic valves. Patients with mild carditis should receive secondary prophylaxis for 10 years after the most recent attack or at least until the age of 25 years, whichever is longer. Congestive heart failure should be managed with standard therapy (Chapters 8 and 9). Aspirin has been traditionally used in a dose of 80 to 100 mg/kg/d given at 4 hourly aliquots in children, and a total of 4 to 8 g/d given in aliquots every 4 to 6 hours for adults. The dose of naproxen used is 10 to 20 mg/kg/d divided in doses every 12 hours with a maximum dose of 1,000 mg in children older than 2 and maximal dose in adults of 1,250 mg. In patients with any degree of cardiac involvement, aspirin is preferred over corticosteroids as steroids may lead to fluid retention and worsen heart failure symptoms. Neither aspirin nor corticosteroids, despite relieving symptoms of inflammation, prevent valvular damage. If intolerant to aspirin, the recommended dose of corticosteroid (prednisone) is 1 to 2 mg/kg/d (maximum of 60 mg/d). Salicylate or steroid therapy does not affect the course of carditis except perhaps in severe carditis where steroids may have a role though this is controversial; therefore, the duration of anti-inflammatory therapy is somewhat arbitrary and is guided by the severity of disease and the response to therapy. Therapy should be continued until there is sufficient clinical and laboratory evidence of disease inactivity. After cessation of anti-inflammatory agents, relapse with mild symptoms may occur. If using a steroid, a gradual reduction in steroid dosing is necessary to avoid relapses. For severe symptoms, treatment with salicylates should be tried before restarting corticosteroids. Early therapy is advisable because it reduces both morbidity and the period of infectivity. Penicillin is the agent of choice primarily for its narrow spectrum of activity, long-standing proven efficacy, and low cost. This preparation is painful; preparations that contain procaine penicillin are less painful. The oral antibiotic of choice is penicillin V (phenoxymethylpenicillin) (see Table 20. A broader spectrum penicillin, such as amoxicillin, offers no microbiologic advantage over penicillin. The recommended dosage is erythromycin estolate or erythromycin ethyl succinate for 10 days. Although uncommon in the United States, strains resistant to erythromycin have been found in some areas of the world and have caused treatment failures. Other macrolides, such as azithromycin, have the advantage of a short treatment duration (5 days) and few gastrointestinal side effects. The recommended dosage is 500 mg as a single dose on the first day followed by 250 mg once daily for 4 days. Another alternative regimen for penicillin-allergic patients is a 10- day course with an oral cephalosporin. A first-generation cephalosporin with a narrower spectrum of action (cefazolin or cephalexin) is preferable to the broader spectrum antibiotics such as cefaclor, cefuroxime, cefixime, and cefpodoxime. Indefinite antibiotic prophylaxis is recommended in patients with severe valvular heart disease. The success of oral prophylaxis depends on the patient’s understanding and adherence to the prescribed regimen.